RAC2 ist ein Gen, das durch das Symbol RAC2 kodiert wird. Es ist auch bekannt als: Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-RAC2. RAC2 hat eine Masse von 21.43kDa, eine Aminosäurelänge von 192, und ist an Neutrophil immunodeficiency syndrome beteiligt.
Wir bieten 7 antikörper gegen RAC2, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Entrez Zusammenfassung
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6.
Gewebespezifität
Hematopoietic specific.
Rolle bei Krankheiten
Neutrophil immunodeficiency syndrome: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing.
Sequenzähnlichkeiten
Belongs to the small GTPase superfamily. Rho family.
Posttranslationale Modifikation
(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
Zellort
Cytoplasm.
Membrane-associated when activated.
