Rabphilin 3A ist ein Gen, das durch das Symbol RPH3A kodiert wird. Es ist auch bekannt als: Rabphilin-3A; Exophilin-1; RPH3A; KIAA0985. Rabphilin 3A hat eine Masse von 76.87kDa und eine Aminosäurelänge von 694.
Wir bieten 6 antikörper gegen Rabphilin 3A, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is thought to be an effector for RAB3A, which is a small G protein that acts in the late stages of neurotransmitter exocytosis. The encoded protein may be involved in neurotransmitter release and synaptic vesicle traffic.
Posttranslationale Modifikation
Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation.
Zellort
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell projection > Dendritic spine. Cell junction > Synapse > Postsynaptic cell membrane. Membrane.
