RAB6A ist ein Gen, das durch das Symbol RAB6A kodiert wird. Es ist auch bekannt als: Ras-related protein Rab-6A; Rab-6; RAB6. RAB6A hat eine Masse von 23.59kDa und eine Aminosäurelänge von 208.
Wir bieten 7 antikörper gegen RAB6A, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).
Entrez Zusammenfassung
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gewebespezifität
Ubiquitous.
Sequenzähnlichkeiten
Belongs to the small GTPase superfamily. Rab family.
Posttranslationale Modifikation
Prenylated.
Zellort
Golgi apparatus membrane.
BICD2 facilitates its targeting to Golgi apparatus membrane.
