Rab5 ist ein Gen, das durch das Symbol RAB5A kodiert wird. Es ist auch bekannt als Ras-related protein Rab-5AA. Rab5 hat eine Masse von 23.66kDa und eine Aminosäurelänge von 215.
Wir bieten 17 antikörper gegen Rab5, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Affe und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Sequenzähnlichkeiten
Belongs to the small GTPase superfamily. Rab family.
Posttranslationale Modifikation
Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.
Zellort
Cell membrane. Early endosome membrane. Melanosome. Cytoplasmic vesicle. Cell projection > Ruffle. Membrane. Cytoplasm > Cytosol. Cytoplasmic vesicle > Phagosome membrane. Endosome membrane.
Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable).
