Rab1A ist ein Gen, das durch das Symbol RAB1A kodiert wird. Es ist auch bekannt als: Ras-related protein Rab-1A; YPT1-related protein; RAB1. Rab1A hat eine Masse von 22.68kDa und eine Aminosäurelänge von 205.
Wir bieten 6 antikörper gegen Rab1A, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
Entrez Zusammenfassung
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms.
Sequenzähnlichkeiten
Belongs to the small GTPase superfamily. Rab family.
Posttranslationale Modifikation
Phosphorylated by CDK1 kinase during mitosis.
Zellort
Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm > Cytosol. Membrane. Melanosome.
Alternates between membrane-associated and cytosolic forms.