PON1 ist ein Gen, das durch das Symbol PON1 kodiert wird. Im Allgemeinen auch bezeichnet als: Serum paraoxonase/arylesterase 1; PON 1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1; PON. PON1 hat eine Masse von 39.73kDa, eine Aminosäurelänge von 355, und ist an Microvascular complications of diabetes 5 beteiligt.
Wir bieten 9 antikörper gegen PON1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Entrez Zusammenfassung
This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7.
Gewebespezifität
Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
Rolle bei Krankheiten
Microvascular complications of diabetes 5: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Sequenzähnlichkeiten
Belongs to the paraoxonase family.
Posttranslationale Modifikation
Glycosylated.
Zellort
Secreted > Extracellular space.
