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Anti-PLCG 2 Antikörper

9 Products

PLCG 2 ist ein Gen, das durch das Symbol PLCG2 kodiert wird. Im Allgemeinen auch bezeichnet als: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2; PLCG2. PLCG 2 hat eine Masse von 147.87kDa, eine Aminosäurelänge von 1265, und ist an folgenden Krankheiten beteiligt: Familial cold autoinflammatory syndrome 3; Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated.

Wir bieten 9 antikörper gegen PLCG 2, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.

Gen- und Proteininformationen

UniProt Zusammenfassung
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Entrez Zusammenfassung
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
Rolle bei Krankheiten
Familial cold autoinflammatory syndrome 3: An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B-cells, defective B-cells, increased susceptibility to infection, and increased risk of autoimmune disorders.

Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated: An autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the gastrointestinal tract. Affected individuals have a mild humoral immune deficiency associated with recurrent sinopulmonary infections, but no evidence of circulating autoantibodies.
Posttranslationale Modifikation
Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.
Western Blot - Anti-PLCG2 (phospho Tyr1217) Antibody (A0553) - Antibodies.com
(3)
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Western Blot - Anti-PLCG2 (phospho Tyr753) Antibody (A0081) - Antibodies.com
(4)
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Western Blot - Anti-PLCG 2 Antibody [ARC1176] (A308453) - Antibodies.com
(4)
Western Blot - Anti-PLCG2 Antibody (B0081) - Antibodies.com
(3)
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Western Blot - Anti-PLCG 2 (phospho Tyr759) Antibody (A88328) - Antibodies.com
(2)
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Western Blot - Anti-PLCG 2 (phospho Tyr1217) Antibody (A88327) - Antibodies.com
(2)
Western Blot - Anti-PLCG 2 Antibody (A13937) - Antibodies.com
(2)
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