PLA2G1B ist ein Gen, das durch das Symbol PLA2G1B kodiert wird. Im Allgemeinen auch bezeichnet als: Phospholipase A2; Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B; PLA2; PLA2A; PPLA2. PLA2G1B hat eine Masse von 16.36kDa und eine Aminosäurelänge von 148.
Wir bieten 7 antikörper gegen PLA2G1B, aufgewachsen in Kaninchen, Ziege und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and Dot mit Proben abgeleitet von Human, Maus, Ratte und Schwein.
Gen- und Proteininformationen
UniProt Zusammenfassung
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Entrez Zusammenfassung
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.
Sequenzähnlichkeiten
Belongs to the phospholipase A2 family.
Posttranslationale Modifikation
Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
Zellort
Secreted.
secreted from pancreatic acinar cells in its inactive form.
