PIAS3 ist ein Gen, das durch das Symbol PIAS3 kodiert wird. Es ist auch bekannt als E3 SUMO-protein ligase E3 SUMO-protein transferase Protein inhibitor of activated STAT protein 3. PIAS3 hat eine Masse von 68.02kDa und eine Aminosäurelänge von 628.
Wir bieten 8 antikörper gegen PIAS3, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Entrez Zusammenfassung
This gene encodes a member of the PIAS
Gewebespezifität
Widely expressed.
Sequenzähnlichkeiten
Belongs to the PIAS family.
Posttranslationale Modifikation
Sumoylated.
Zellort
Cytoplasm. Nucleus. Nucleus speckle.
Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules.
