PIAS1 ist ein Gen, das durch das Symbol PIAS1 kodiert wird. Im Allgemeinen auch bezeichnet als: E3 SUMO-protein ligase DEAD/H box-binding protein 1; E3 SUMO-protein transferase Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein; DDXBP1. PIAS1 hat eine Masse von 71.84kDa und eine Aminosäurelänge von 651.
Wir bieten 7 antikörper gegen PIAS1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants.
Gewebespezifität
Expressed in numerous tissues with highest level in testis.
Sequenzähnlichkeiten
Belongs to the PIAS family.
Posttranslationale Modifikation
Sumoylated.
Zellort
Nucleus speckle. Nucleus > PML body.
Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
