PI 3 Kinase Class 3 ist ein Gen, das durch das Symbol PIK3C3 kodiert wird. Im Allgemeinen auch bezeichnet als: Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34; PIK3C3; VPS34. PI 3 Kinase Class 3 hat eine Masse von 101.55kDa und eine Aminosäurelänge von 887.
Wir bieten 6 antikörper gegen PI 3 Kinase Class 3, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
Gewebespezifität
Ubiquitously expressed, with a highest expression in skeletal muscle.
Sequenzähnlichkeiten
Belongs to the PI3/PI4-kinase family.
Zellort
Midbody. Late endosome. Cytoplasmic vesicle > Autophagosome.
As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (Probable). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).
