Phospholipase A2 ist ein Gen, das durch das Symbol PLA2G2A kodiert wird. Im Allgemeinen auch bezeichnet als: Phospholipase A2, membrane associated; GIIC sPLA2; Group IIA Non-pancreatic secretory NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; PLA2G2A; PLA2B; PLA2L; RASF-A. Phospholipase A2 hat eine Masse von 16.08kDa und eine Aminosäurelänge von 144.
Wir bieten 14 antikörper gegen Phospholipase A2, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and Dot mit Proben abgeleitet von Human, Maus, Ratte, Rind und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).
Entrez Zusammenfassung
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene.
Sequenzähnlichkeiten
Belongs to the phospholipase A2 family.
Zellort
Cell membrane. Secreted.
