Perilipin-1 ist ein Gen, das durch das Symbol PLIN1 kodiert wird. Im Allgemeinen auch bezeichnet als: Lipid droplet-associated protein; PLIN1; PERI; PLIN. Perilipin-1 hat eine Masse von 55.99kDa, eine Aminosäurelänge von 522, und ist an Lipodystrophy, familial partial, 4 beteiligt.
Wir bieten 7 antikörper gegen Perilipin-1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Entrez Zusammenfassung
The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene.
Gewebespezifität
Detected in adipocytes from white adipose tissue (at protein level) (PubMed:27832861). Detected in visceral adipose tissue and mammary gland (PubMed:9521880).
Rolle bei Krankheiten
Lipodystrophy, familial partial, 4: A form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension.
Sequenzähnlichkeiten
Belongs to the perilipin family.
Posttranslationale Modifikation
Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).
Zellort
Endoplasmic reticulum. Lipid droplet.
Lipid droplet surface-associated.
