PDE8A ist ein Gen, das durch das Symbol PDE8A kodiert wird. Es ist auch bekannt als High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A. PDE8A hat eine Masse von 93.3kDa und eine Aminosäurelänge von 829.
Wir bieten 12 antikörper gegen PDE8A, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).
Entrez Zusammenfassung
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
Sequenzähnlichkeiten
Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
Posttranslationale Modifikation
Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.
