PDE4A ist ein Gen, das durch das Symbol PDE4A kodiert wird. Im Allgemeinen auch bezeichnet als: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; DPDE2; PDE46. PDE4A hat eine Masse von 98.14kDa und eine Aminosäurelänge von 886.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gewebespezifität
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
Sequenzähnlichkeiten
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Posttranslationale Modifikation
Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.
Zellort
Cytoplasm > Perinuclear region.
