PDE10A ist ein Gen, das durch das Symbol PDE10A kodiert wird. Es ist auch bekannt als cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A. PDE10A hat eine Masse von 88.41kDa, eine Aminosäurelänge von 779, und ist an folgenden Krankheiten beteiligt: Dyskinesia, limb and orofacial, infantile-onset; Striatal degeneration, autosomal dominant 2.
Wir bieten 11 antikörper gegen PDE10A, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Gewebespezifität
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Rolle bei Krankheiten
Dyskinesia, limb and orofacial, infantile-onset: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.
Striatal degeneration, autosomal dominant 2: An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
Sequenzähnlichkeiten
Belongs to the cyclic nucleotide phosphodiesterase family.
Posttranslationale Modifikation
Phosphorylated on Thr-16.
Zellort
Cytoplasm.
Located mostly to soluble cellular fractions.
