PD-L1 ist ein Gen, das durch das Symbol CD274 kodiert wird. Im Allgemeinen auch bezeichnet als: Programmed cell death 1 ligand 1; B7 homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1. PD-L1 hat eine Masse von 33.28kDa und eine Aminosäurelänge von 290.
Wir bieten 94 antikörper gegen PD-L1, aufgewachsen in Kaninchen, Maus, Ziege und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte, Kaninchen, Hund und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
Entrez Zusammenfassung
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Posttranslationale Modifikation
Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
Zellort
Cell membrane. Early endosome membrane. Recycling endosome membrane.
Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation.
