Pannexin 1 ist ein Gen, das durch das Symbol PANX1 kodiert wird. Im Allgemeinen auch bezeichnet als: Pannexin-1; PANX1; MRS1. Pannexin 1 hat eine Masse von 48.05kDa, eine Aminosäurelänge von 426, und ist an Oocyte maturation defect 7 beteiligt.
Wir bieten 9 antikörper gegen Pannexin 1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116).
Entrez Zusammenfassung
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.
Gewebespezifität
Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116).
Rolle bei Krankheiten
Oocyte maturation defect 7: An autosomal dominant infertility disorder due to oocyte degeneration and death, which may occur before or after fertilization.
Sequenzähnlichkeiten
Belongs to the pannexin family.
Posttranslationale Modifikation
S-nitrosylation inhibits channel currents and ATP release.
Zellort
Cell membrane. Cell junction > Gap junction. Endoplasmic reticulum membrane.
