PAK5 ist ein Gen, das durch das Symbol PAK5 kodiert wird. Im Allgemeinen auch bezeichnet als: Serine/threonine-protein kinase PAK 5; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7; KIAA1264; PAK7. PAK5 hat eine Masse von 80.75kDa und eine Aminosäurelänge von 719.
Wir bieten 7 antikörper gegen PAK5, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
Gewebespezifität
Predominantly expressed in brain.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Posttranslationale Modifikation
Autophosphorylated when activated by CDC42/p21.
Zellort
Mitochondrion. Cytoplasm. Nucleus.
Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
