P70 S6 Kinase beta ist ein Gen, das durch das Symbol RPS6KB2 kodiert wird. Im Allgemeinen auch bezeichnet als: Ribosomal protein S6 kinase beta-2; S6K-beta-2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; RPS6KB2; STK14B. P70 S6 Kinase beta hat eine Masse von 53.46kDa und eine Aminosäurelänge von 482.
Wir bieten 7 antikörper gegen P70 S6 Kinase beta, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
Entrez Zusammenfassung
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Posttranslationale Modifikation
Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
Zellort
Cytoplasm. Nucleus.
