P2Y12 ist ein Gen, das durch das Symbol P2RY12 kodiert wird. Im Allgemeinen auch bezeichnet als: P2Y purinoceptor 12; ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc) platelet ADP receptor; P2Y(ADP); SP1999; P2RY12; HORK3. P2Y12 hat eine Masse von 39.44kDa, eine Aminosäurelänge von 342, und ist an Bleeding disorder, platelet-type 8 beteiligt.
Wir bieten 6 antikörper gegen P2Y12, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Entrez Zusammenfassung
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.
Gewebespezifität
Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
Rolle bei Krankheiten
Bleeding disorder, platelet-type 8: A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
