Oligodendrocyte Specific Protein ist ein Gen, das durch das Symbol CLDN11 kodiert wird. Im Allgemeinen auch bezeichnet als: Claudin-11; Oligodendrocyte-specific protein; CLDN11; OSP; OTM. Oligodendrocyte Specific Protein hat eine Masse von 21.99kDa und eine Aminosäurelänge von 207.
Wir bieten 6 antikörper gegen Oligodendrocyte Specific Protein, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Entrez Zusammenfassung
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Sequenzähnlichkeiten
Belongs to the claudin family.
Zellort
Cell junction > Tight junction. Cell membrane.
