Ogg1 ist ein Gen, das durch das Symbol OGG1 kodiert wird. Im Allgemeinen auch bezeichnet als: N-glycosylase/DNA lyase; MMH; MUTM; OGH1. Ogg1 hat eine Masse von 38.78kDa, eine Aminosäurelänge von 345, und ist an Renal cell carcinoma beteiligt.
Wir bieten 8 antikörper gegen Ogg1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Entrez Zusammenfassung
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
Gewebespezifität
Ubiquitous.
Rolle bei Krankheiten
Renal cell carcinoma: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
Sequenzähnlichkeiten
Belongs to the type-1 OGG1 family.
Zellort
Nucleus > Nucleoplasm. Nucleus speckle. Nucleus matrix.
Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
