Occludin ist ein Gen, das durch das Symbol OCLN kodiert wird. Es ist auch bekannt als OCLN. Occludin hat eine Masse von 59.14kDa, eine Aminosäurelänge von 522, und ist an Pseudo-TORCH syndrome 1 beteiligt.
Wir bieten 18 antikörper gegen Occludin, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB and IHC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.
Entrez Zusammenfassung
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
Gewebespezifität
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Rolle bei Krankheiten
Pseudo-TORCH syndrome 1: An autosomal recessive neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.
Sequenzähnlichkeiten
Belongs to the ELL/occludin family.
Posttranslationale Modifikation
Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1.
Zellort
Cell membrane. Cell junction > Tight junction.
