Nurr1 ist ein Gen, das durch das Symbol NR4A2 kodiert wird. Im Allgemeinen auch bezeichnet als: Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor Transcriptionally-inducible nuclear receptor; NR4A2; NOT; TINUR. Nurr1 hat eine Masse von 66.59kDa und eine Aminosäurelänge von 598.
Wir bieten 6 antikörper gegen Nurr1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and IP mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gewebespezifität
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
Sequenzähnlichkeiten
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Zellort
Cytoplasm. Nucleus.
Mostly nuclear; oxidative stress promotes cytoplasmic localization.
