NUMB ist ein Gen, das durch das Symbol NUMB kodiert wird. Im Allgemeinen auch bezeichnet als: Protein numb homolog; h-Protein S171; C14orf41. NUMB hat eine Masse von 70.8kDa und eine Aminosäurelänge von 651.
Wir bieten 7 antikörper gegen NUMB, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Entrez Zusammenfassung
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants.
Posttranslationale Modifikation
Phosphorylated on Ser-276 and Ser-295 by CaMK1.
