Nucleoporin p62 ist ein Gen, das durch das Symbol NUP62 kodiert wird. Im Allgemeinen auch bezeichnet als: Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62; NUP62. Nucleoporin p62 hat eine Masse von 53.26kDa, eine Aminosäurelänge von 522, und ist an Infantile striatonigral degeneration beteiligt.
Wir bieten 6 antikörper gegen Nucleoporin p62, aufgewachsen in Kaninchen, Ziege und Ratte, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630).
Entrez Zusammenfassung
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.
Rolle bei Krankheiten
Infantile striatonigral degeneration: Neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and mental retardation.
Sequenzähnlichkeiten
Belongs to the nucleoporin NSP1/NUP62 family.
Posttranslationale Modifikation
O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.
Zellort
Nucleus > Nuclear pore complex. Cytoplasm > Cytoskeleton > Spindle pole. Nucleus envelope. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.
Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630).
