Nucleolin ist ein Gen, das durch das Symbol NCL kodiert wird. Im Allgemeinen auch bezeichnet als: Protein C23; NCL. Nucleolin hat eine Masse von 76.61kDa und eine Aminosäurelänge von 710.
Wir bieten 24 antikörper gegen Nucleolin, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte, Affe und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Entrez Zusammenfassung
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
Posttranslationale Modifikation
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).
Zellort
Nucleus > Nucleolus. Cytoplasm.
Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
