Nkx3.1 ist ein Gen, das durch das Symbol NKX3-1 kodiert wird. Im Allgemeinen auch bezeichnet als: Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A; NKX3-1; NKX3A. Nkx3.1 hat eine Masse von 26.35kDa und eine Aminosäurelänge von 234.
Wir bieten 25 antikörper gegen Nkx3.1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Entrez Zusammenfassung
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
Gewebespezifität
Highly expressed in the prostate and, at a lower level, in the testis.
Sequenzähnlichkeiten
Belongs to the NK-3 homeobox family.
Posttranslationale Modifikation
Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
