NFAT5 ist ein Gen, das durch das Symbol NFAT5 kodiert wird. Im Allgemeinen auch bezeichnet als: Nuclear factor of activated T-cells 5; NF-AT5; T-cell transcription factor Tonicity-responsive enhancer-binding protein; TonE-binding protein; KIAA0827; TONEBP. NFAT5 hat eine Masse von 165.76kDa und eine Aminosäurelänge von 1531.
Wir bieten 7 antikörper gegen NFAT5, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).
Entrez Zusammenfassung
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.
Posttranslationale Modifikation
Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322).
Zellort
Nucleus. Cytoplasm.
Nuclear distribution increases under hypertonic conditions.
