Neurotrophin 4 ist ein Gen, das durch das Symbol NTF4 kodiert wird. Im Allgemeinen auch bezeichnet als: Neurotrophin-4; NT-4; Neurotrophin-5; NT-5; Neutrophic factor 4; NTF4; NTF5. Neurotrophin 4 hat eine Masse von 22.43kDa, eine Aminosäurelänge von 210, und ist an Glaucoma 1, open angle, O beteiligt.
Wir bieten 6 antikörper gegen Neurotrophin 4, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Target-derived survival factor for peripheral sensory sympathetic neurons.
Entrez Zusammenfassung
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
Gewebespezifität
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
Rolle bei Krankheiten
Glaucoma 1, open angle, O: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Sequenzähnlichkeiten
Belongs to the NGF-beta family.
