Neuropeptide Y ist ein Gen, das durch das Symbol NPY kodiert wird. Es ist auch bekannt als Pro-NPY. Neuropeptide Y hat eine Masse von 10.85kDa und eine Aminosäurelänge von 97.
Wir bieten 6 antikörper gegen Neuropeptide Y, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Entrez Zusammenfassung
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
Gewebespezifität
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Sequenzähnlichkeiten
Belongs to the NPY family.
Posttranslationale Modifikation
The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Zellort
Secreted. Cytoplasmic vesicle > Secretory vesicle > Neuronal dense core vesicle.
