NEK7 ist ein Gen, das durch das Symbol NEK7 kodiert wird. Im Allgemeinen auch bezeichnet als: Serine/threonine-protein kinase Never in mitosis A-related kinase 7; NimA-related protein kinase 7. NEK7 hat eine Masse von 34.55kDa und eine Aminosäurelänge von 302.
Wir bieten 7 antikörper gegen NEK7, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.
Entrez Zusammenfassung
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.
Gewebespezifität
Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Posttranslationale Modifikation
Phosphorylation at Ser-195 required for its activation.
Zellort
Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Spindle pole. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.
Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity).
