NCR3 ist ein Gen, das durch das Symbol NCR3 kodiert wird. Im Allgemeinen auch bezeichnet als: Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; 1C7; LY117. NCR3 hat eine Masse von 21.59kDa und eine Aminosäurelänge von 201.
Wir bieten 10 antikörper gegen NCR3, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Entrez Zusammenfassung
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
Sequenzähnlichkeiten
Belongs to the natural cytotoxicity receptor (NCR) family.
