Nck beta ist ein Gen, das durch das Symbol NCK2 kodiert wird. Im Allgemeinen auch bezeichnet als: Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta; NCK2; GRB4. Nck beta hat eine Masse von 42.92kDa und eine Aminosäurelänge von 380.
Wir bieten 6 antikörper gegen Nck beta, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Entrez Zusammenfassung
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gewebespezifität
Ubiquitous.
Posttranslationale Modifikation
Phosphorylated.
Zellort
Cytoplasm. Endoplasmic reticulum.
