N Cadherin ist ein Gen, das durch das Symbol CDH2 kodiert wird. Im Allgemeinen auch bezeichnet als: Cadherin-2; CDw325; Neural cadherin; N-cadherin; CDH2; CDHN; NCAD. N Cadherin hat eine Masse von 99.81kDa und eine Aminosäurelänge von 906.
Wir bieten 35 antikörper gegen N Cadherin, aufgewachsen in Kaninchen, Maus, Ziege und Ratte, welche geeignet sind für WB, IHC, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Affe, Huhn und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Entrez Zusammenfassung
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone.
Posttranslationale Modifikation
Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).
Zellort
Cell membrane. Cell membrane > Sarcolemma. Cell junction. Cell surface.
Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes.
