Myosin Light Chain 2 ist ein Gen, das durch das Symbol MYL2 kodiert wird. Im Allgemeinen auch bezeichnet als: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; Cardiac Myosin light chain 2, slow skeletal/ventricular muscle isoform; MLC-2s/v; Ventricular MYL2; MLC2. Myosin Light Chain 2 hat eine Masse von 18.79kDa, eine Aminosäurelänge von 166, und ist an Cardiomyopathy, familial hypertrophic 10 beteiligt.
Wir bieten 7 antikörper gegen Myosin Light Chain 2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
Entrez Zusammenfassung
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Rolle bei Krankheiten
Cardiomyopathy, familial hypertrophic 10: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
Posttranslationale Modifikation
N-terminus is methylated by METTL11A/NTM1.
Zellort
Cytoplasm > Myofibril > Sarcomere > A band.
