Myeloid leukemia factor 1 ist ein Gen, das durch das Symbol MLF1 kodiert wird. Es ist auch bekannt als Myelodysplasia-MLF1. Myeloid leukemia factor 1 hat eine Masse von 30.63kDa und eine Aminosäurelänge von 268.
Wir bieten 6 antikörper gegen Myeloid leukemia factor 1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Entrez Zusammenfassung
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Sequenzähnlichkeiten
Belongs to the MLF family.
Posttranslationale Modifikation
Phosphorylation is required for binding to YWHAZ.
Zellort
Cytoplasm. Nucleus. Cell projection > Cilium. Cytoplasm > Cytoskeleton > Cilium basal body.
Shuttles between the cytoplasm and nucleus.
