Myelin oligodendrocyte glycoprotein ist ein Gen, das durch das Symbol MOG kodiert wird. Im Allgemeinen auch bezeichnet als: Myelin-oligodendrocyte glycoprotein; MOG. Myelin oligodendrocyte glycoprotein hat eine Masse von 28.19kDa, eine Aminosäurelänge von 247, und ist an Narcolepsy 7 beteiligt.
Wir bieten 5 antikörper gegen Myelin oligodendrocyte glycoprotein, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
Entrez Zusammenfassung
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gewebespezifität
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Rolle bei Krankheiten
Narcolepsy 7: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. BTN/MOG family.
