MUC2 ist ein Gen, das durch das Symbol MUC2 kodiert wird. Im Allgemeinen auch bezeichnet als: Mucin-2; MUC-2; Intestinal mucin-2; SMUC. MUC2 hat eine Masse von 540.3kDa und eine Aminosäurelänge von 5179.
Wir bieten 19 antikörper gegen MUC2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Entrez Zusammenfassung
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
Gewebespezifität
Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Posttranslationale Modifikation
O-glycosylated.
Zellort
Secreted.
In the intestine, secreted into the inner and outer mucus layers.
