mSin3A ist ein Gen, das durch das Symbol SIN3A kodiert wird. Im Allgemeinen auch bezeichnet als: Paired amphipathic helix protein Sin3a; Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a; SIN3A. mSin3A hat eine Masse von 145.18kDa, eine Aminosäurelänge von 1273, und ist an Witteveen-Kolk syndrome beteiligt.
Wir bieten 6 antikörper gegen mSin3A, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ICC/IF, IP and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Gewebespezifität
Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
Rolle bei Krankheiten
Witteveen-Kolk syndrome: An autosomal dominant syndrome characterized by global developmental delay, mild to severe intellectual disability, and facial dysmorphism. Additional features include short stature, microcephaly, joint hypermotility, and small hands and feet with digital abnormalities. Brain imaging shows dilated ventricles, thin corpus callosum and, in some cases, dysgyria or polymicrogyria.
Posttranslationale Modifikation
SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
Zellort
Nucleus. Nucleus > Nucleolus.
Recruited to the nucleolus by SAP30L.
