MPP1 ist ein Gen, das durch das Symbol MPP1 kodiert wird. Im Allgemeinen auch bezeichnet als: 55 kDa erythrocyte membrane protein; p55; Membrane protein, palmitoylated 1; DXS552E; EMP55. MPP1 hat eine Masse von 52.3kDa und eine Aminosäurelänge von 466.
Wir bieten 6 antikörper gegen MPP1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
Entrez Zusammenfassung
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Ubiquitous.
Sequenzähnlichkeiten
Belongs to the MAGUK family.
Posttranslationale Modifikation
Palmitoylated.
Zellort
Cell membrane. Cell projection > Stereocilium.
Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM) (By similarity). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) (By similarity). Colocalizes with NF2 in non-myelin-forming Schwann cells (PubMed:19144871).
