MMP16 ist ein Gen, das durch das Symbol MMP16 kodiert wird. Im Allgemeinen auch bezeichnet als: Matrix metalloproteinase-16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; C8orf57; MMPX2. MMP16 hat eine Masse von 69.52kDa und eine Aminosäurelänge von 607.
Wir bieten 6 antikörper gegen MMP16, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Entrez Zusammenfassung
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Gewebespezifität
Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
Sequenzähnlichkeiten
Belongs to the peptidase M10A family.
Posttranslationale Modifikation
The precursor is cleaved by a furin endopeptidase.
Zellort
Cell membrane.
Localized at the cell surface of melanoma cells.
