MMP12 ist ein Gen, das durch das Symbol MMP12 kodiert wird. Im Allgemeinen auch bezeichnet als: Macrophage metalloelastase; MME; Macrophage elastase; ME; Matrix metalloproteinase-12; MMP-12; HME. MMP12 hat eine Masse von 54kDa und eine Aminosäurelänge von 470.
Wir bieten 10 antikörper gegen MMP12, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Entrez Zusammenfassung
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11.
Gewebespezifität
Found in alveolar macrophages but not in peripheral blood monocytes.
Sequenzähnlichkeiten
Belongs to the peptidase M10A family.
Zellort
Secreted > Extracellular space > Extracellular matrix.
