Metallothionein ist ein Gen, das durch das Symbol MT2A kodiert wird. Im Allgemeinen auch bezeichnet als: Metallothionein-2; MT-2-2A-II; MT-II; MT2A; CES1; MT2. Metallothionein hat eine Masse von 6.04kDa und eine Aminosäurelänge von 61.
Wir bieten 9 antikörper gegen Metallothionein, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Entrez Zusammenfassung
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity.
Sequenzähnlichkeiten
Belongs to the metallothionein superfamily. Type 1 family.
