MelanA ist ein Gen, das durch das Symbol MLANA kodiert wird. Im Allgemeinen auch bezeichnet als: Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MLANA; MART1. MelanA hat eine Masse von 13.16kDa und eine Aminosäurelänge von 118.
Wir bieten 44 antikörper gegen MelanA, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ICC/IF, FC and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Hund und Pferd.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Gewebespezifität
Expression is restricted to melanoma and melanocyte cell lines and retina.
Posttranslationale Modifikation
Acylated.
Zellort
Endoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus > trans-Golgi network membrane. Melanosome.
Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
