MEK5 ist ein Gen, das durch das Symbol MAP2K5 kodiert wird. Im Allgemeinen auch bezeichnet als: Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MEK 5; MAP2K5; MKK5; PRKMK5. MEK5 hat eine Masse von 50.11kDa und eine Aminosäurelänge von 448.
Wir bieten 7 antikörper gegen MEK5, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte, Rind, Huhn, Hund, Xenopus und Zebrafisch.
Gen- und Proteininformationen
UniProt Zusammenfassung
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Entrez Zusammenfassung
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Gewebespezifität
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Posttranslationale Modifikation
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
