MAX ist ein Gen, das durch das Symbol MAX kodiert wird. Im Allgemeinen auch bezeichnet als: Protein Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X; BHLHD4. MAX hat eine Masse von 18.28kDa, eine Aminosäurelänge von 160, und ist an Pheochromocytoma beteiligt.
Wir bieten 13 antikörper gegen MAX, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
Gewebespezifität
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Rolle bei Krankheiten
Pheochromocytoma: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
Sequenzähnlichkeiten
Belongs to the MAX family.
Posttranslationale Modifikation
Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
Zellort
Nucleus. Cell projection > Dendrite.
