MAGEA4 ist ein Gen, das durch das Symbol MAGEA4 kodiert wird. Im Allgemeinen auch bezeichnet als: Melanoma-associated antigen 4; Cancer/testis antigen 1.4; CT1.4; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen; MAGE4. MAGEA4 hat eine Masse von 34.9kDa und eine Aminosäurelänge von 317.
Wir bieten 7 antikörper gegen MAGEA4, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
Entrez Zusammenfassung
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.
Gewebespezifität
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
