MAdCAM1 ist ein Gen, das durch das Symbol MADCAM1 kodiert wird. Im Allgemeinen auch bezeichnet als: Mucosal addressin cell adhesion molecule 1; MAdCAM-1. MAdCAM1 hat eine Masse von 40.16kDa und eine Aminosäurelänge von 382.
Wir bieten 10 antikörper gegen MAdCAM1, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Entrez Zusammenfassung
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
Gewebespezifität
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Posttranslationale Modifikation
The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
